How to freeze dry liquids

Freeze dryer is a technique of drying by using the principle of sublimation. It is to freeze the dried material at low temperature and then sublimate the frozen water molecules in a proper vacuum oven environment. It is a process that makes frozen water molecules into water vapor evolution.

The vacuum system of the freeze dryer consists of a freeze dryer, a water vapor condenser, a vacuum valve, and a vacuum pump. The degree of vacuum during lyophilization is approximately 67 to 0.13 Pa (5 x 10-1 to 1 x 10-3Torr). The pre-vacuum of the freeze-drying system requires that the required vacuum should be achieved in about 30 minutes.

Then people maybe wonder how to freeze dry liquids, next let’s go through the process together : Before freeze drying materials, we need to compound the materials into liquids with certain concentration. And materials that need to be freeze dried should be compounded into liquids with 4%-25% solid substances concentration(10%-15% is the best), so that the materials could have a good shape finally. The freeze-drying process generally consists of three steps: pre-freezing, sublimation drying (or the first stage drying), analytical drying (or the second stage drying).

Firstly, pre-freezing is to solidify the free water in the solution and give the product the same shape after drying as before, and to prevent irreversible changes such as foaming. Secondly, when frozen products are heated in sealed vacuum containers, their ice crystals will sublimate to vapor and escape, resulting in dehydration and drying of the products. Thirdly, in order to improve the storage stability and prolong the shelf life of the product, it is necessary to remove moisture that is adsorbed on the capillary wall and polar groups of dry matter.

Does freeze drying remove water

  As we talked above, freeze drying is to freeze materials into solid-phase firstly and then sublimate water within these solid materials directly into vapor. So in this process, water within materials get into ice and then gas. And finally water within materials get out of the materials as vapor. Therefore, freeze drying removes water in this way.

How long does freeze drying take

  Many people wonder “how long does freeze drying take”? The answer is “it depends”. Now let me tell you the reason. The time that freeze drying takes varies because of the different applications and conditions of freeze drying. Generally, it takes one day or two days for freeze drying to work. Freeze drying mostly takes one day or two days and there are still some exceptional examples.

What is the difference between freeze drying and Lyophilization

  Freeze drying and Lyophilization are very similar but there are still some differences here between the two. They both are methods that is to freeze materials into solid-phase and then sublimate water within them into gas-phase directly under vacuum. Freeze drying and Lyophilization can be different from each other when they are in different industrial situations and venues.

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